Synthesis of Some New Substituted Aminoacylthiazoles and Dipeptide Derivatives

A.M. Gommaa*, M.F. Badie, M.S. Latif and M.H. Hakim
Chemistry Department, Faculty of Science Al-Azhar University, Nasr City, Cairo, Egypt
Abstract

Coupling of N-phthalyl- or N-tosylamino acids with 4-p-tolyl- (or 4-p-chlorophenyl-) 2-aminothiazole (I-II) using the dicyclohexylcarbodiimide (DCC) method furnishes 2-(N-phthalyl- or N-tosylaminoacyl) amino-4-p-tolyl-thiazoles (III -XII) and the corresponding 4-p-chlorophenylthiazoles (XXIII-XXXII). Hydrazinolysis of 2-(N-phthalylaminoacyl) amino-4-p-tolyl-(or 4-p-chloraphenyl-) thiazoles (III-VII and XXIII-XXVIII) in ethanol afforded the desired 2-(aminoacyl) amino-4-p-tolyl-or (4-p-chlorophenyl-) thiazoles (XIII-XVII and XXXIII-XXXVII). 2-(N-Tosyldipeptidyl) amino-4-p-tolyl-( or 4-p-chlorophenyl-thiazoles (XVIII-XXII and XXXVIII-XLII) were synthesized via the DCC method. Some of the synthesized compounds were found to be active against a number of micro-organisms.

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  • Asian J. Chem. /
  •  1992 /
  •  4(3) /
  •  pp 527-533