Synthesis of Some New 3,4/4,6-Disubstituted- 1,2,4-Trianine-5-Ones Bearing a Pyrazoleo-Pyridazine Moiety

M.M. Fawzy, R.M. Abdel-Rahman* and Z. El-Gendy

Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt  


The synthesis of3,4-disubstituted-6-dihydro-1 ,2,4-triazine-5(H) one (IV), 4,6-disubstituted-1,2,4-triazine-5 (3H) ones (IX), 4,5,6-trisubstituted-3,5-dihydro-1,2,4-triazine(XII), 4,6-disubstituted-3H-5-dihydro-1,2,4-triazine (XIII) and 4-substituted-1,3,5,6-hexahydro-1,2,4-triazine(XIV) have been accomplished starting from α-hydrazinocarboxamide III and formyl-hydrazone VIII by the reaction with acid halides, α-oxoacids, α-haloketones and α,β-bihalocompounds. The structure of all new prepared compounds were elucidated on the basis of chemical and spectroscopic data.


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  • Asian J. Chem. /
  •  1992 /
  •  4(3) /
  •  pp 500-507