Jitendra Patel^1,*,, G. Shiva Kumar^1, and Vijay K. Patel^2,

¹Gitam School of Pharmacy, GITAM Deemed to be University, Rudraram (V), Sangareddy (D), Hyderabad-502329, India

²Institute of Pharmaceutical Sciences, Guru Ghasidas University, (A Central University), Bilaspur-495009, India

*Corresponding author: E-mail: jpatel@gitam.edu

Pathogens spread on food items during the stages of storage, transit and processing. Thus, the eradication of these microorganisms holds significant importance. Ethanolic extract of Terminalia coriacea was used against Escherichia coli NCIM2134, Pseudomonas aeroginosa NCIM2037, Klebsiella pneumonia NCIM2706, Bacillus subtilis NCIM2920, Staphylococcus aureus NCIM5345 and Staphylococcus epidermidis NCIM5755 by disk diffusion and microdilution methods to evaluate the antibacterial activity. The ethanolic extract of Terminalia coriacea (Roxb.) leaves gave significant activity against all tested species of bacteria, which was compared to the standard disinfectant of 0.1% of commercial chlorhexidine. The inhibitions zones ranged from 6.45 ± 0.82 to 9.52 ± 0.30 for different bacterial strains. The minimum inhibitory concentration (MIC) was observed, ranging from 0.73 mg/mL to 1.35 mg/mL and the minimum bactericidal concentration (MBC) was observed, ranging from 0.73 mg/mL to 2.50 mg/mL. Based on the obtained results, it is suggested that the T. coriacea demonstrates antimicrobial properties against both Gram-positive and Gram-negative bacterial strains commonly encountered in food products. This plant extract can be further developed for the sanitizing of food items.

Antibacterial activity, Terminalia coriacea, Chlorhexidine, Disk diffusion test, Microdilution.