Synthesis, Spectral Characterization and Biological Evaluation of Glutaric Acid based Macrocyclic Complexes

Rajrani Gulia1, Vikas Sangwan2, and Anshul Singh1,*,

1Department of Chemistry, Baba Mastnath University, Rohtak-124021, India

2Department of Chemistry, R.P.S. Degree College, Mahendergarh-123029, India

*Corresponding author: E-mail:


In the presence of divalent transition metal ions, glutaric acid and o-phenylenediamine were used to design and synthesize a unique series of macrocyclic complexes. The UV-visible, IR, ESR and ESI-MS spectroscopic methods were used to analyze these newly designed complexes. In order to evaluate their thermal behaviour, TGA analysis was employed. The general formula for the synthesized complexes was [M(L)X2] (L = ligand, X = Cl and M = Co2+, Ni2+ and Cu2+). The central metal ions are surrounded by octahedral environment. These macrocyclic complexes were tested for their antimicrobial effectiveness against the selected bacterial strains (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli), as well as fungi strains (Aspergillus niger and Candida albicans) and their efficacy was compared to that of standard drugs streptomycin and itraconazole, respectively. Moreover, the antioxidant activity of the macrocyclic complexes were also assessed using the DPPH assay.


Antifungal, Antibacterial, Glutaric acid, Tetraaza macrocyclic complexes, DPPH assay.

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