Synthesis and Evaluation of Analgesic and Antioxidant Activity of 3-Phenyl Coumarin Derivatives

P. Adsule*,, D. Purandare, S. Kulkarni, R. Joshi and A. Chabukswar

School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, Pune-411038, India

*Corresponding author: Fax: +91 20 25460616; E-mail:


A series of 3-phenyl substituted coumarin derivatives were synthesized by reacting substituted aromatic aldehyde with phenylacetic acid. The chemical composition of substituted coumarin derivatives was confirmed by FT-IR, 1H NMR spectra and elemental analysis. All the 3-phenyl coumarin derivatives were docked with cyclooxygenase-2 (COX-2) enzyme (PDB code: 3Q7D). Compounds were synthesized and evaluated for in vivo analgesic and in vitro antioxidant activities depending upon the highest binding affinity. Compounds 2, 10 and 11 exhibited significant analgesic activity, while compounds 1, 3, 4 and 9 showed significant antioxidant potential in the DPPH method and compounds 5 and 7 have shown excellent scavenging potential in the nitric oxide scavenging method compared to ascorbic acid.


3-Phenyl coumarin, Molecular docking, Analgesic activity, Antioxidant activity.

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