| Synthesis of Novel Isoxazoline/Isoxzolyl Pyrano Heterocyclic Annulated Flavones |
Rachakonda Sydhulua and Yerrabelly Hemasria* |
Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India
*Corresponding author: E-mail: hemay2@yahoo.com |
| Abstract
The synthesis of new isoxazoline/isoxazole pyrano fused flavone derivatives from 6-hydroxy 5-formyl flavone via in situ generation of nitrile oxide from aldoxime using ceric ammonium nitrate (CAN) as an oxidant followed by intramolecular cycloaddition reaction at olefin/alkyne functions is reported in high yields. The reaction involves regio selective annulation at C5/C6 position in preference to the C6/C7 position of flavones. All the synthesized compounds were successfully characterized by IR, 1H NMR, 13C NMR and ESI-MS. |
| Keywords
1,3-Dipolar cycloaddition, Flavone aldoximes, Flavone-isoxazoline/isoxazole, Ceric ammonium nitrate. |
| |
View Article 
This work is licensed under a Creative Commons Attribution 4.0 International License.
|
|
|
|