Vanita Marvaniya^1,*,, Hirak V. Joshi^2,, Ujashkumar A. Shah^2, and Jayvadan K. Patel^2,

¹Department of Quality Assurance and Pharmaceutical Chemistry, Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India

²Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, S.K. Campus, Kamana Cross Road, Visnagar-384315, India

*Corresponding author: E-mail: vanitapatel512@gmail.com

A new series of diaryl urea derivatives bearing pyridine moiety were designed, synthesized and evaluated for their biological activity. In this study, we applied the structure-based virtual screening (SBVS) on the high similar sorafenib approved drug, selected from the DrugBank database as well as on a series of derivatives, selected from the literature. Aim was to provide new potent anticancer agents. Analysis was performed using AutoDock VINA tools. Based on the ligand binding energy. Compounds will be synthesized by chlorination of pyridine acid derivative which further coupled with amine and form amide, amide further reaction with aminophenolic moiety and form ether which is react with other aromatic amine using CDI to produce final compound and these compounds characterized by IR, NMR and mass spectroscopic techniques. The synthesized derivatives have been evaluated to their anticancer activity in vitro by MTT assay using MCF-7 cell line. The anticancer activity indicates that compounds C1, C3, C6 and C9 have better anticancer activity.

Diaryl urea derivatives, Anticancer agents, Molecular docking, MTT assay.