Design, Synthesis, Molecular Docking Studies and Biological Evaluation of Indole Fused Novel Pyrazole Derivatives

N. Prasanna Lakshmi1,*, and M. Ajitha2

1Department of Pharmacy, Sri Venkateshwara College of Pharmacy, Hyderabad-500081, India

2JNTUH-University College of Pharmaceutical Sciences, Sultanpur (Village), Pulkal (Mandal), Sangareddy District-502273, India

*Corresponding author: E-mail: lucky6prasanna@gmail.com

Abstract

The present work deals with the sequence of indole fused novel pyrazole compounds (5a-l) synthesized by conventional method and were screened for anthelmintic, anticancer activities and molecular docking studies. All the newly synthesized compounds were characterized by IR, 1H NMR and Mass spectral analysis. Further, all the pyrazole derivatives were screened for anthelmintic activity using albendazole as standard drug and anticancer activity against MCF-7 and SKVO3 cell lines by MTT assay method. The results showed that compounds 5b and 5j exhibited good anticancer activity and compounds 5c, 5f, 5h and 5l exhibited potential anthelmintic activity. Additionally, the molecular docking studies of novel pyrazole derivatives were carried out to explain putative bonding interaction between the active site of EGFR enzyme and potent inhibitors.

Keywords

Pyrazole, Isatin, Phenyl hydrazine, Anthelmintic activity, Anticancer activities, MCF-7, SKVO3.

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