p-TSA Catalyzed Synthesis of Tetrahydrobenzo[g]quinolines via Multicomponent Reaction using Pyrazole Aldehyde, Lawsone, β-Ketoesters and Ammonium Acetate

Kittappa Gunasundari, Selvaraj Jayanthi, Sreedharan Helen Perci, Moorthy Vetriselvan and Manickam Pramesh*,

PG and Research Department of Chemistry, A.V.V.M. Sri Pushpam College, Poondi-613503, India

*Corresponding author: E-mail: mprameshchemistry@gmail.com


An efficient protocol has been developed for the multicomponent synthesis of tetrahydrobenzo[g]quinoline-3-carboxylate derivatives using p-toluenesulfonic acid (p-TSA) as catalyst through one-pot four component condensation reaction of pyrazole aldehyde, Lawsone, β-ketoesters and ammonium acetate in ethanol. The synthesized compounds were characterized by spectroscopic techniques.


Tetrahydrobenzoquinoline, Pyrazole aldehydes, Lawsone, p-Toluenesulfonic acid.

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