Fluoroquinolones Metal Complexes as Potent Antibacterial Agents: A Review

Savita Khatri1, Manoj Kumar1, Harkesh Sehrawat1, S.P. Khatkar2, V.B. Taxak2 and Rajesh Kumar1,*,

1Department of Chemistry, University Institute of Engineering & Technology, Maharshi Dayanand University, Rohtak-124001, India

2Department of Chemistry, Maharshi Dayanand University, Rohtak-124001, India

*Corresponding author: E-mail: lather_rajesh@yahoo.com

Abstract

In this review article, a brief discussion of fluoroquinolones (FQs) and their tendency to form metal complexes is presented. The effect of FQs-M complexes on disease causing microorganisms is also summarized. The antibacterial activity of various metal complexes of various fluoroquinolones [norfloxacin (NOR), ciprofloxacin (CIP), levofloxacin (LEVO), ofloxacin (OFL), gemifloxacin (GEMI), gatifloxacin (GATI), moxifloxacin (MOX), enrofloxacin (ENRO), sparfloxacin (SPRX)] is reviewed by comparing zone of inhibition and MIC values of metal complexes. It is found to be either corresponding with the parent fluoroquinolone or in some cases their respective metal complexes exhibit stronger antibacterial activity. New approach towards synthesis of FQ-metal complexes has led to formation of compounds with the anticancer and antiviral activity.

Keywords

Fluoroquinolones, Metal chelates, IR spectra, Antibacterial activities.

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