Evaluation of Cu-Ag Bimetallic Nanoalloys as Antibacterial, Antidiabetic, Anticancerous Drug Biosynthesized from Curcuma aromatica

Jasmine Jacob1,*,, T. Augustine Arul Prasad1,, B. Scholastica Mary Vithiya2,, Bindhu Thomas1 and R. Vasanthi1

1Post Graduate and Research Department of Chemistry, Dwarakadoss Goverdhan Doss Vaishnav College (Affiliated to University of Madras, Chennai-600005), India

2Post Graduate and Research Department of Chemistry, Auxilium College (Affiliated to Thiruvalluvar University, Vellore-632115), India

*Corresponding author: E-mail: jasminejacob215@gmail.com

Abstract

Drug resistant strains are formed due to unsuitable uses of antibiotics and insufficient check of infections. In present years, due to the extensive antimicrobial properties, metallic nanoparticles and metallo-pharmaceutics are highly proposed. Therefore, the synthesis of bimetallic nanoparticles are exploring towards the evolution of more productive amalgamative antimicrobials composed of combined metals. In this study, the green synthesis of Cu-Ag bimetallic nano-alloys using aqueous extract from the leaves of Curcuma aromatica is carried out. Synthesized Cu-Ag nano-alloys were characterized by UV-visible spectroscopy, scanning electron microscope (FE-SEM), transmission electron microscope (TEM-EDAX), cyclic voltammogram (CV). The characterization studies reveals that the biosynthesis produced core-shell Cu-Ag nano-alloys with spherical shape and average diameter size of 15 nm. The synthesized Cu-Ag nanoalloys exhibited antibacterial activity against both Gram-positive and Gram-negative bacteria. The antidiabetic potential of Cu-Ag nanoalloys shows an effective inhibition against α-glucosidase. Anticancerous activity of Cu-Ag nanoalloys indicates its greater efficacy in destroying cancer cells. The biosynthesis of Cu-Ag nanoalloys can be employed in medical and industrial fields on a large scale with cost reductive method.

Keywords

Bimetallic nanoparticles, Curcuma aromatica, Antibacterial activity, Antidiabetic activity, Anticancerous activity.

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