A Short Review on Recent Applications of Chitosan Biopolymer in Gene and Drug Delivery

Sreehari Suresh, Mridul Umesh*, and Suma Sarojini

Department of Life Sciences, CHRIST (Deemed to be University), Bangalore-560029, India

*Corresponding author: E-mail: mridul.umesh@christuniversity.in

Abstract

The battle of the human race with genetic disorders was prevailing from the time immemorial. Revolutions and modernizations in science and technology have clearly improved our understanding regarding the molecular basis of genetic disorders thereby aiding in designing new therapeutic interventions in their treatment and prevention. With the advent and development of gene therapy in the last few decades, promising windows were opened for treatment and prevention of genetic disorders and cancer. Despite of its remarkable significance in medicine, the common practice of using viral vectors as gene delivery agents has created controversies and concerns among the scientific community. This made the research focus on biobased polymers as alternative non-viral vector systems for gene and drug delivery for treating genetic disorders and cancer. Chitosan is a cationic polymer that can be easily tailored to serve as gene and drug delivery due to their biocompatibility and biodegradability. Their structural integrity and stability have made them widely used for various applications in the biomedical field. Chitosan and its derivatives have gained more attention as vectors for gene delivery and cancer therapy in the past decade. The amenability of structural modification, non-toxicity and high biodegradability of chitosan derivatives can make them prospective carriers for controlled drug delivery in future.

Keywords

Chitosan, Gene therapy, Drug delivery, Biopolymers, Gene delivery, Vectors.

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