Synthesis, Characterization and Biological Screening of Novel Imidazolylpyrazole Scaffolds

Jyotsna Sharma1,, Hardeep Singh Tuli2,, Mayank Kinger3,, Ram Pal4,, Zahoor Abbas1, and Manoj Kumar1,*,

1Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134007, India

2Department of Biotechnology, Maharishi Markandeshwar (Deemed to be)University, Mullana-Ambala-133207, India

3Department of Chemistry, Chaudhary Bansi Lal University, Bhiwani-127021, India

4R&D, SRF Limited, Chemicals Technology Group, Tijara-301019, India

*Corresponding author: E-mail: manojraju27@gmail.com

Abstract

A novel series of 3-(4-aryl)-4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-pyrazole was synthesized by employing the well-known Debus-Radziszewski reaction. Structures of all the newly synthesized compounds have been characterized by various spectroscopic techniques viz. FTIR, 1H and 13C NMR, LC-MS and elemental analysis. All these compounds were also screened for antimicrobial potential against bacterial strains of S. aureus, K. pneumoniae and fungal strains of A. niger and T. rubrum.

Keywords

Heterocycles, Vilsmeier-Haack reaction, Imidazolylpyrazole hybrids, Benzil, Antimicrobial activity.

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