Bonding Ability of Isopthalic Acid-bis(thiosemicarbozone) to Manganese and Cobalt Metal Ions: Preparation, Spectral Investigation, Computational and in vitro Antipathogenic Screening

S. Gautam1,2,*,, P. Pipil3,, A. Kumar4, Alka1,5, J. Singh1,, Ravikant2, S. Singhal1 and S.K. Sagar6

1Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India

2Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN Marg, New Delhi-110002, India

3Department of Chemistry, Rajdhani College, University of Delhi, Raja Garden, Ring Road, New Delhi-110015, India

4Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi-110003, India

5SRM-IST, Delhi-NCR Campus, Modinagar, Ghaziabad-201204, India

6Department of Zoology, Swami Shraddhanand College, University of Delhi, Alipur Road, Delhi-110036, India

*Corresponding author: E-mail:


Manganese and cobalt complexes have been designed and prepared with a tetradentate ligand i.e. isopthalic acid-bis(thiosemicarbozone) (IPBT), which bind to metal ions via donor atoms present in ligand. Different spectroscopic techniques viz. nuclear magnetic resonance, infrared, mass, electronic spin resonance and analytical studies have been used to determine the chemical composition of synthesized IPBT and its Mn(II) and Co(II) complexes. The spectroscopic data exposed that IPBT behaves in a tetradentate (N2S2) mode by having ability to bind with metal ions through N2S2 atoms. An octahedral structure for manganese and cobalt complexes has been suggested on the basis of spectroscopic as well as analytical studies. The ligand (IPBT) and its metal(II) complexes have been screened to determine their antipathogenic activity against some selective microorganisms S. aureus, P. aeruginosa, E. coli, A. niger, M. phasolina and P. glomerata. In this experimental work, well diffusion and poisoned food techniques have been introduced for screening purpose and as standard drugs neomycin and chlorothalonil have been used. Data for antipathogenic screening exposed that metal complexes exerted higher activity towards all examined microbes (bacteria and fungi) even than ligand.


Tetradentate ligand, Isopthalic acid, Metal complexes, Antimicrobial screening, Poisoned food method.

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