Synthesis and Spectral Studies of Piprazine Schiff Base Lanthanide(III) Complexes and their Microbial and Anticancer Activity

V. Geethalakshmi1,, N. Nalini2,, S.S. Sabithamala2,, D. Tamilselvi1, and C.T. Theivarasu3,

1Department of Chemistry, Rathinam Technical Campus, Coimbatore-641021, India

2Department of Chemistry, Sri Krishna College of Technology, Coimbatore-641042, India

3Department of Chemistry, PSG College of Technology, Coimbatore-641004, India

*Corresponding author: E-mail:


A novel Schiff base ligand has been synthesized by the condensation reaction of 1-(2-amino ethyl)piprazine with o-vanillin in methanol solution. Using lanthanide(III) metal ions (Ln3+ = La3+, Ce3+, Pr3+, Nd3+, Sm3+ and Gd3+) in methanol, six complexes of piprazine Schiff base were synthesized. All the lanthanide(III) complexes were characterized by IR, UV, NMR, TG-DTA, X-ray diffraction analysis and photoluminence. According to the spectral analysis piprazine act as a bidentate monobasic donor coordinating through the azomethine nitrogen and a phenyl oxygen atom. Antimicrobial studies of the synthesized compounds were evaluated and reported. Anticancer activities were also studied towards the human breast cancer cell line (MCF-7).


Schiff base, lanthanide(III) complexes, Antimicrobial activity, Anticancer activity.

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