Fabrication of Minerals Substituted Hydroxyapatite based Nanocomposite Coating on Titanium: Physico-Chemical and in vitro Biological Evaluations

K. Sofiya*, and G. Bharath Kumar

Biomaterials in Medicinal Chemistry Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625021, India

*Corresponding author: E-mail: rajanm153@gmail.com

Abstract

The search of orthopedic metallic implants which facilitate osteoconductivity and mitigate bacterial contamination has received substantial care to ensure long-term problems in the biomedical sector. Current research studies electrophoretic deposition of gelatin (Gel)@minerals (Ce, Mg, Zn) substituted hydroxyapatite (MHA2)-halloysite nanotube (HNT)-single-walled carbon nanotubes (SWCNT) (Gel@MHA2-HNT-SWCNT) nanocomposite coatings on the surface of titanium plate. Coated samples were characterized by FTIR, XRD and SEM-EDX techniques. Furthermore, antimicrobial, hemolysis and cell viability studies of coating materials and their findings show the bacteriostatic activity, hemocompatibility and more viable cells, respectively. Overall, the in vitro experiments have shown that Gel@MHA2-HNT-SWCNT nanocomposite coating on titanium enhanced the biocompatible efficiency, suggesting that Gel@MHA2-HNT-SWCNT coated titanium is a potential implant substrate for orthopedic implants.

Keywords

Bone, Gelatin, Nanocomposite, Implant, Osteoblast compatibility.

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