A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives

Nidhi Dhama1,2,*,, Sucheta2,, Aadesh Kumar1,, Vikrant Verma1, and Sunil Kumar2,

1Department of Pharmaceutical Chemistry, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut-250005,, India

2Department of Pharmaceutical chemistry, K.R. Mangalam University, Sohna Road, Sohna Rural-122103, India

*Corresponding author: E-mail: nidhi.dhama.9693@gmail.com


Piracetam is generally utilized as a nootropic drug, which is normally used in the treatment of CNS disorders. Piracetam is a cyclic compound and a derivative of γ-aminobutyric acid and improves learning, memory, brain metabolism, and ability. This drug belongs to the racetams group with the chemical name 2-oxo-1-pyrrolidine acetamide. The emphasis of this review article is to highlight different biological activities associated with piracetam and also some of its synthetic methodologies. Promising effects have been achieved in the management and treatment of several diseases for example alcoholism, Raynaud’s phenomenon, deep vein thrombosis and brain injury.


Cognitive disorders, Piracetam, GABA derivatives, CNS disorder, Nootropic drug.

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