Tathagata Dey^1,2, and Indira Viswambaran Asharani^1,*,

¹Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

²Department of Pharmaceutical Chemistry, East Point College of Pharmacy, Bangalore-560049, India

*Corresponding author: E-mail: asharani.iv@vit.ac.in

Among heterocycles, a wide variety of nitrogen heterocycles have been exploited to develop pharmaceutically important molecules. Particularly, acridines are clinically used potential drug candidates showing various pharmacological activities. Some of the novel m-PEG attached acridinediones 4(a-j) were synthesized with the readily available starting materials such as dimedone, glycine and aldehydes. Structures of the synthesized compounds were characterized by spectral techniques. The synthesized compounds (4a-j) were evaluated for in vitro antimicrobial, antioxidant and anticancer activities. Compounds 4d, 4e and 4g were found to produce potent antimicrobial activities against Gram-positive and Gram-negative organisms while 4c active against only Gram-positive organisms when compared with the standard, ciprofloxacin. On the other side, 4d and 4i produced potent antioxidant activity and 4a, 4d and 4g exhibited comparable anticancer properties.

Acridinedione, Antimicrobial, Antioxidant, Anticancer.