Synthesis of New Class of Functionalized Flavones/Isoxazole Derivatives-Nitrile oxide 1,3-Dipolar Cycloaddition

Neeradi Balaiah and Yerrabelly Hemasri*

Department of Chemistry, Nizam College, Osmania University, Hyderabad-500001, India

*Corresponding author: E-mail: hemay2@yahoo.com

Abstract

A new series of functionalized flavone-isoxazole derivatives have been synthesized from alkyne tethered 3-hydroxy flavone by adopting facile synthetic method, intermolecular nitrile oxide 1,3-dipolar cycloaddition in the presence of eco-friendly sodium hypochloride oxidant under mild reaction conditions. Structures of all the synthesized compounds were established on the basis of 1H NMR, 13C NMR and ESI-mass.

Keywords

Propargyloxy flavone, Nitrile oxide, 1,3-Dipolar cycloaddition, Flavone, Isoxazole.

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