Review on Synthesis Route of Quinazoline Based Hybrid Derivatives

Pravin Deharkar*,, Shridhar Satpute and Deepa Panhekar

Department of Chemistry, Dr. Ambedkar College, Deekshabhoomi, Nagpur-440010, India

*Corresponding author: E-mail:


Quinazolines are amidst the most significant pharmacological compounds in natural and medicinal chemistry, with a wide variety of pharmacological things, including antifungal, antibacterial, anti-inflammatory, anti-HIV, anticancer and analgesic activity. Designing innovative quinazolines, studying possible techniques to synthesize quinazolines, examining diverse features of quinazolines and looking for prospective uses of quinazolines have all become more important in the last two decades due to their multiple possible applications. The current review paper discusses the synthesis of quinazolines using the multi-component synthetic technique that is environmentally friendly, mild and atom-efficient. The discussion is separated into sections based on the key processes used to construct quinazoline scaffolds to provide an efficient approach for a more significant grasp. The most recent references have also been taken into account. The review should prove useful in future research on quinazoline synthesis and developing a more promising synthetic technique.


Bicyclic compounds, Pyrimidine, Amidines, Nitriles, Synthesis, Green chemistry, Quinazolines, Quinazolinones.

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