Identification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy

M. Chandra Sekhara Rao1,2, R. Chenna Krishna Reddy2,3, K.B. Chandra Sekhar2 and Y.V. Rami Reddy1,*

1Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

2Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515002, India.

3Department of Science and Humanities, Sri Venkateswara College of Engineering, Karakambadi Road, Tirupati-517507, India

*Corresponding author: E-mail:


A simple FT-Raman spectroscopic method was developed for identification of finasteride polymorph form in finished dosage form. Finasteride polymorph form I was used in the tablet preparation and the weight fraction of finasteride in tablet was only about 0.023. The method was successfully used to identify the polymorphic form of finasteride in tablet and also to detect up to a level of about 15% of the other polymorph of finasteride present in the solid dosage. The dosage form was characterized by different techniques i.e. powdered X-ray diffraction, infrared spectroscopy and Raman spectroscopy. Based on literature survey, only Raman spectroscopy method is able to identify the polymorph of finasteride in dosage form.


Identification, FT-Raman spectroscopy, Polymorphs, Finasteride.

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