Efficient Synthesis of Novel Thiazole Substituted Pyrrolidine Derivatives and their Antimicrobial Evaluation

Mahendra B. Bodake1,, Ghanshyam R. Jadhav1,, Vijay J. Medhane1,2,*, and Avinash D. Bholay3

1Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India

2Department of Chemistry, S.V.K.T. College (Affiliated to Savitribai Phule Pune University, Pune), Deolali Camp, Nashik-422401, India

3P.G. Department of Microbiology, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India

*Corresponding author: E-mail: vjmedhane1664@gmail.com

Abstract

A series of new molecules containing pyrrolidine and thiazole moiety (4a-l) were designed and synthesized. The structures of the synthesized compounds were characterized by IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activity against strains of bacteria as well as antifungal activity against fungal strains. Minimum inhibitory concentrations (MICs) of all the synthesized compounds were determined. The screening of title compounds revealed that most of the tested compounds showed moderate to good microbial inhibitions.

Keywords

Pyrrolidine, Thiazole, Antimicrobial activity.

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