Novel Acetohydrazide Pyrazole Derivatives: Design, Synthesis, Characterization and Antimicrobial Activity

Anil Verma1, Vinod Kumar1,2, Ramesh Kataria3 and Joginder Singh1,*

1Department of Chemistry, Maharishi Markandeshwar University (Deemed to be University), Mullana-133201, India

2Department of Chemistry, Central University of Haryana, Mahendergarh-123031, India

3Department of Chemistry, Panjab University, Chandigarh-160014, India

*Corresponding author: Fax: +91 1731 274375; Tel: +91 1731 304100; E-mail:


Eleven acetohydrazide linked pyrazole derivatives were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. 6b, 6c and 6d were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives as compared to other groups present in the ring. Hence, among compounds 6b-c, compound 6d could be explored further against other microbes to prove its vitality.


Acetohydrazide pyrazoles, Antimicrobial activity.

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