A Novel Synthesis, Characterization and Biological Studies of Ferrocenyl Substituted Pyrazoles

Manoj Kumar1,*, Shashi Sharma1, Hardeep Singh Tuli2, Rajshree Khare3 and Vinit Parkash1

1Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134003, India

2Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, India

3Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala- 133207, India

*Corresponding author: E-mail: manojraju27@gmail.com

Abstract

It has been discovered that ferrocenyl substituted heterocyclic compounds have wide scope of restorative methodology. The combination of ferrocenyl substituted pyrazole is the new class in these compounds with upgraded natural activity. This work center around blend of ferrocenyl substituted pyrazoles through novel course. The combination of 1-phenyl-3-ferrocenyl-pyrazole was examined including addition-cyclocondensation like response conditions. The response continued through three phases using of expansion cyclo-buildup of acetyl ferrocene with phenyl hydrazine pursued by cyclizing reagent iodine with NaHCO3. In both syntheses, each time single product isolated having good yields (87 and 79 %). Ferrocenyl substituted pyrazoles were examined by spectroscopic techniques (1H NMR, IR, MS) and their biological properties have been screened.

Keywords

Ferrocenyl substituted pyrazoles, Addition cyclo-condensation, Biological activities.

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