Synthesis, Characterization and Biological Studies of Novel Biodegradable Aconitic Acid Based Copolyester for Application in Skin Tissue Engineering

Vanitha Krishna Kumar and Nanthini Raveendiran*

Department of Chemistry, Pachaiyappa’s College, University of Madras, Chennai-600 030, India

*Corresponding author: Fax: +91 44 26426900; Tel: +91 44 26412094; E-mail: vanabhava@yahoo.co.in

Abstract

Biodegradable polyester elastomers have gained a greater attention in the field of skin tissue engineering. A series of novel biodegradable polyesters are synthesized, based on non toxic monomers e.g., aconitic acid, citric acid and 1,12-dodoecanediol, which are usually extracted from natural components. In the present work, a co-polyester poly (1,12-dodecanediol acotinate-co-1,12-dodecanediol citrate) (PACDDL) is synthesized by melt poly-condensation without any toxic catalyst. The chemical structure of the elastomers are then characterized by FT-IR, 1H NMR and 13C NMR. TGA, DSC techniques. The biological studies such as, in vitro cyto-compatibility, anticancer activity and CAM assay (angiogenesis) are examined. The physical properties exhibit that the elastomer is suitable for application in tissue engineering. The biological studies reveal that the polymer has excellent cell compatibility, making it suitable as potent biomaterial in skin tissue engineering.

Keywords

Aconitic acid, Elastomers, Biomedical application, Angiogenesis, Anticancer activity.

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