Potent Antimicrobial Agents of 8-Aza-bicyclo[3.2.1]octyl hydrazide Derivatives: Synthesis and Biological Evaluation

T. Lakshmi Viveka1,* and L. Nalanda Sharada2

1Department of Chemistry, VNR Vignana Jyothi Institute of Engineering and Technology, Bachupally, Hyderabad-500 090, India

2Department of Chemistry, University College of Science, Osmania University, Hyderabad-500 007, India

*Corresponding author: E-mail: lakshmiviveka99@gmail.com


A facile synthesis of 8-aza-bicyclo[3.2.1]octyl hydrazide derivatives 4(a-m) can be achieved by modified Mannich reaction. Novelty of this research involves one pot synthesis of new modified Mannich based triazole derivatives using aromatic aldehydes and active hydrogen containing amides in the presence of ammonia and primary amine. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectroscopy. Among all the compounds which are screened for antibacterial and antifungal activities, hydrogen containing thiosemicarbazide moiety and 4,4-diflorocyclohexane carboxylic hydrazide has shown better activity against four bacterial strains and two fungal strains.


Mannich reaction, Triazoles, Hydrazides, Biological activity.

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