| Synthesis and Characterization of Potential Pharmacopeial Impurities of Oseltamivir: An Antiviral Drug |
Rajasekhar Ponduri1,2,*, Pramod Kumar2, Lakshmana Rao Vadali1, Komaraiah Aelugu1 and Kishore Matcha1 |
1Mylan Laboratories Limited, Bollaram, Jinnaram (Mandal), Medak-502 325, India
2Jawaharlal Nehru Technological University-Hyderabad, College of Engineering, Centre for Chemical Sciences & Technology, Institute of Science and Technology, Kukatpally, Hyderabad-500 085, India
*Corresponding author: E-mail: rajasekharponduri123@gmail.com |
| Abstract
Impurities of oseltamivir phosphate were synthesized from chiral epoxide (1) in a simpler and much feasible synthetic approach in seven steps accounting to 8.2 % overall yield. The nucleophilic addition of N3 (highly regioselective and stereoselective) in the first and third stage of the synthesis has been tailored and the reaction conditions were optimized. |
| Keywords
Oseltamivir, Impurities, Antiviral, Aziridine. |
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