Synthesis and Characterization of Potential Pharmacopeial Impurities of Oseltamivir: An Antiviral Drug

Rajasekhar Ponduri1,2,*, Pramod Kumar2, Lakshmana Rao Vadali1, Komaraiah Aelugu1 and Kishore Matcha1

1Mylan Laboratories Limited, Bollaram, Jinnaram (Mandal), Medak-502 325, India

2Jawaharlal Nehru Technological University-Hyderabad, College of Engineering, Centre for Chemical Sciences & Technology, Institute of Science and Technology, Kukatpally, Hyderabad-500 085, India

*Corresponding author: E-mail: rajasekharponduri123@gmail.com

Abstract

Impurities of oseltamivir phosphate were synthesized from chiral epoxide (1) in a simpler and much feasible synthetic approach in seven steps accounting to 8.2 % overall yield. The nucleophilic addition of N3 (highly regioselective and stereoselective) in the first and third stage of the synthesis has been tailored and the reaction conditions were optimized.

Keywords

Oseltamivir, Impurities, Antiviral, Aziridine.

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