One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-thione Derivatives Using DBU as Green and Recyclable Catalyst

T. Sekhar, P. Thriveni*, M. Harikrishna and K. Murali

Department of Chemistry, Vikrama Simhapuri University, Nellore-524 003, India

*Corresponding author: E-mail:


A short and simple one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-thione derivatives was accomplished in excellent yields by reaction of aryl ketone, aryl aldehydes and thiourea in aqueous ethanol (50 %) using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a reusable catalyst.


Green synthesis, 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), Pyrimidine-2(1H)-thione, Multicomponent synthesis.

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