N.H. Zamakshshari¹, G.C.L. Ee^1,*, S. Daud², S.S. Teh³ and S.H. Mah⁴

¹Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

²Faculty of Applied Science, Mara University of Technology Pahang Campus, Bandar Jengka, 26400 Bandar Tun Razak, Pahang, Malaysia

³Energy and Environment Unit, Engineering & Processing Division, Malaysian Palm Oil Board, 43000 Kajang, Selangor, Malaysia

⁴School of Biosciences, Taylor's University (Lakeside campus) 1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia

*Corresponding author: Fax: +60 3 89435380; Tel.: +60 3 89466785; E-mail: gwendolinechenglian@gmail.com

A phytochemical investigation on the stem bark of Calophyllum depressinervosum resulted in the isolation of four xanthones, one coumarin and one kavalactone which were elucidated to be caloxanthone B (1), caloxanthone I (2), caloxanthone J (3), xanthochymone B (4), calopolynolide B (5) and desmethoxyyangonim (6). The structures of the compounds were elucidated using spectroscopic analysis such as 1D and 2D NMR together with MS technique. The dichloromethane extract of Calophyllum depressinervosum gave good cell viability on RAW246.7 cells for potential antiinflammatory test with an IC₅₀ value of 17.19 ± 0.007 μg/mL.

Calophyllum depressinervosum, Xanthone, Coumarin, Kavalactones, Antiinflammatory.