Antibacterial Efficacy of Halloysite Nanotube Minerals Substituted Hydroxyapatite Composite on Titanium Alloy using Electrodeposition Method

Manickam Chozhanathmisra1, Dharman Govindaraj2, Palanisamy Karthikeyan1 and Rangappan Rajavel1,*

1Department of Chemistry, Periyar University, Salem-636 011, India

2Biomaterials in Medicinal Chemistry Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, India

*Corresponding author: Fax: +91 427 2345124; Tel: +91 427 2345271, E-mail:


Bacterial infections are the most common and serious complications for titanium based implants in the biomedical industry, and the ideal implant specimens should combine as an excellent bioactivity and good antibacterial ability. Therefore, the antibacterial agents containing composites coated with implant surfaces to prevent the bacterial infections. The present study is an investigation of the effect of hydroxyapatite exclusion on the corrosion resistivity, antibacterial behaviour, and bioactivity of HNT-PEDOT-MHA composite coatings on titanium alloy surfaces. Antibacterial tests showed that pure hydroxyapatite coating did not exhibit any antibacterial activity, whereas the presence of Zn2+ in hydroxyapatite composite resulted in a good activity against S. aureus and E. coli. Potentiodynamic polarization tests were performed on both modified hydroxyapatite (MHA) and nanotube halloysite (HNT) as incorporated with poly(3,4-ethylenedioxythiophene) (PEDOT) coatings shows a better anticorrosion property when compared to uncoated titanium alloy, it also has an excellent biological activity in biomedical applications.


Biomedical, Antibacterial agents, Composites, Bacterial infections, Corrosion resistivity.

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