Physical Interaction Between Water-Soluble Poly(Acrylamide/Itaconic Acid) with Acriflavine and Procainamide Hydrochloride

C. Hepokur1, S. Misir1, A.I. Kariper2,* and A.I. Hepokur3

1Department of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, 58140 Sivas, Turkey

2Faculty of Education, Erciyes University, Kayseri, Turkey

3Department of Physiology, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey

*Corresponding author: Fax: +90 346 2191634; Tel: +90 346 2191010 ext. 3913; E-mail: akariper@gmail.com; cozsoya@gmail.com

Abstract

In this study, the water-soluble polymers, poly(itaconic acid acrylamide) (PAI) and poly(acrylamide) (PAAm), were synthesized through radical addition reactions. Structural characterization of poly(itaconic acids acrylamide) and poly(acrylamide) was performed by Fourier transform infrared and scanning electron microscope. Release and anti-release profile of the pharmaceutical active agents [acriflavine (AF) and procainamide hydrochloride (PH)] from the polymers (PAI and PAAm) were monitored by ultraviolet-visible spectrophotometry. It has been observed that the entire drug (1 mg procainamide hydrochloride), which was added to the solution with 1 g of polymer, was absorbed in around 3 h by poly(itaconic acids acrylamide). Also, 0.6 mg of acriflavine drug was absorbed in around 3 h. Thus, poly(itaconic acids acrylamide) and poly(acrylamide) polymers were tested for acriflavine and procainamide hydrochloride drugs. In the light of these results, the polymers that are suitable for the release of acriflavine and procainamide hydrochloride drugs were identified.

Keywords

Acrylamide, Itaconic acid, Procainamide hydrochloride, Acriflavine, Water-soluble polymers.

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