Synthesis, Spectral and Biological Studies of Cu(II), Ni(II), Fe(III), Co(II), Mn(II) and Cd(II) Complexes of 3-Acetyl-4-hydroxy-6-methyl-2H-pyran- 2-one Schiff Base Derived from 3-Amino-1,2,4-triazole

D.G. Palke and S.D. Salunke*

Department of Chemistry & Analytical Chemistry, Rajarshi Shahu Mahavidyalaya (Autonomous), Latur-413 512, India

*Corresponding author: Fax: +91 2382 253645; Tel: +91 2382 245933; E-mail: salunke_shridhar@yahoo.co.in

Abstract

The solid metal complexes of Cu(II), Ni(II), Fe(III), Co(II) Mn(II) and Cd(II) with novel Schiff base ligand derived from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one and aromatic primary amine, 3-amino-1,2,4-triazole were synthesized and characterized by elemental analysis, FTIR, UV-visible, 1H NMR and XRD spectroscopic techniques. The signals of 1H NMR spectra and important bands in IR spectra are considered and discussed in relation to molecular structure of ligand. The UV-visible absorption bands are assigned to corresponding electronic transitions, which are also studied by magnetic study. The biological (antibacterial and antifungal) activity of ligand and its metal complexes have been screened in vitro against Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans. Schiff base ligand as well as all metal complexes have shown significant biological activities.

Keywords

3-Acetyl-4-hydroxy-6-methyl-2H-pyran-2-one, Schiff bases, Metal complexes, Biological activity.

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