Improved Method of S-Alkylation of 2-Mercaptobenzimidazole Derivatives with Trialkylphosphite

A. El-Kihel1,*, S. Zouitina1,2, S. Guesmi2, M. Ahbala1, P. Bauchat3 and B. Biersack4

1Laboratoire de Chimie Bioorganique, Faculté des Sciences, BP20, 24000, El Jadida, Morocco

2Laboratoire de Chimie de Coordination et d'Analytique, Faculté des Sciences, BP20, 24000, El Jadida, Morocco

3Université de Rennes1, Sciences Chimiques de Rennes U.M.R. 6226, ICMV, Campus de Beaulieu, Avenue Général Leclerc, 35042, Rennes, France

4Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, NW 1, 95447 Bayreuth, Germany

*Corresponding author: E-mail: abdellatifelkihel@gmail.com

Abstract

A new method of S-alkylation of 2-mercaptobenzimidazole derivatives has been developed by the condensation of these heterocycles with trialkylphosphite in the presence of phosphorus oxychloride giving the corresponding 2-S-alkylbenzimidazoles. The structure of the obtained products has been established by spectroscopic data.

Keywords

2-Mercaptobenzimidazole, 2-S-alkylbenzimidazoles, Trialkylphosphite, Phosphorus oxychloride, S-alkylation.

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