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Simultaneous Determination of Tramadol and Diltiazem in Waterbodies by Capillary Electrophoresis with End-Column Electrochemiluminescence Detection

Yue Dong and Erbao Liu*

School of Chemistry and Materials Science, Shanxi Normal University, Linfen 041000, P.R. China

*Corresponding author: Tel/Fax: +86 357 2051895, E-mail: liueb@dns.sxnu.edu.cn; liueb123@163.com
Abstract

A novel and sensitive method was proposed for determination of tramadol and diltiazem concentrations in water using capillary electrophoresis coupled with electrochemiluminescence. The effects of experimental conditions were investigated. Under optimized conditions, the calibration plot was linear over tramadol concentrations in the range 6 × 10-6 to 3 × 10-4 mol/L (r ³ 0.997), with a detection limit (S/N = 3) of 3.012 × 10-8 mol/L, diltiazem concentrations in the range 5 × 10-7 to 2 × 10-4 mol/L (r ³ 0.986), with a detection limit of 1.038 × 10-8 mol/L (S/N = 3). For the determination of tramadol and diltiazem concentrations in waterbodies, the relative standard deviation (RSD) of electrochemiluminescence intensity and migration time were and 4.55 % to 4.58 %, 1.73 % to 2.01 %, 0.72 % to 1.39 % and 0.97 % and 1.11 %, respectively. The proposed method was simple, rapid, sensitive and also had the merits of good reproducibility without external interference, on small samples. It was applied to determine tramadol and diltiazem concentrations in lake water samples which showed higher recoveries thereof. The new set-up was able to detect a matrix of samples both directly and simultaneously.
Keywords

Capillary electrophoresis, Diltiazem, Electrochemiluminescence, Tramadol.
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