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Metals as Renewable Catalysts in MCR Synthesis of Dihydropyrimidinones

Humaira Firdous1, Ansa Madeeha Zafar2, Muhammad Naeem Khan3,*, Najma Parveen4, Munawar Ali Munawar1 and Misbahul Ain Khan1,2

1Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan

2Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

3Applied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore, Pakistan

4Department of Chemistry, The Government Sadiq College Women University, Bahawalpur, Pakistan

*Corresponding author: E-mail: changwani_1@yahoo.com
Abstract

Various metals (Cu, Fe, Al and Zn) have been successfully employed in the MCR of aryl carbaldehydes, ethyl acetoacetate and urea to give respective dihydropyrimidinones in good to excellent yields. The catalysts in these reactions are easily recovered and used many times without losing its catalytic activity. The products were duly characterized through their spectral analysis.
Keywords

Biginelli synthesis, Zn, Cu, Al, Fe, Pyrimidines.
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