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Synthesis and Crystal Structure of Novel 9-Styrylquinoline Substituted Acridines as Potential Inhibitors of Bacteria

Jia-Juan Qi1,2, Shu-An Li2,*, Zhen-Ming Zhang1,2, Ting Wang1,2, Hong-Bo Zhao1,2, Xuan Wang1,2 and Fu-Jun Yin2

1School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, P.R. China

2Jiangsu Province R&D Institute of Marine Resources, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

*Corresponding author: E-mail: li_shu_an@163.com; qjj581@163.com
Abstract

Novel compounds of 1,8-dioxodecahydroacridines were designed as potential inhibitors of bacteria and prepared via the multi-component reaction of styrylquinoline aldehydes, dimedone and ammonium acetate in high yield under mild condition. The structure of products has been characterized by X-ray crystal structural analyses, 1H NMR, IR, LC-MC and elemental analysis. The preliminary biological screening shows that target product display a certain degree of activity against the vibrio harveyi at 100 μg mL-1.
Keywords

1,8-Dioxodecahydroacridines, Antibacterial activities, Quinolines moiety, Three component reactions.
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