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Characterization of Hypoglycemic Constituents in Momordica charantia L. and their Hypoglycemic Effect

Shan-Bin Guo1, Yue Tian2 and Ling-Yan Jian1,*

1Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, P.R. China

2Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, P.R. China

*Corresponding author: Tel: +86 24 9661571101: E-mail: jianlingyan126@126.com; kangtg@126.com
Abstract

This study represents the active constituents in Momordica charantia L. and their hypoglycemic effect. Active constituents in Momordica charantia L. were extracted by ethanol percolation extraction and purified by macroporous resin method and preparative thin layer chromatography, post-administration blood glucose in mice was measured using mice model of STZ diabetes. Four compounds were isolated from Momordica charantia L., the determination of blood glucose, hepatic glycogen and fructosamine in mice indicated that blood glucose in mice was lowered after administration of Momordica charantia L. It is suggested that Momordica charantia L. has a hypoglycemic effect.
Keywords

Momordica charantia L., Aglycone, Momordicoside, Diabetic mice model.
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