Optimization of Process Variables in Esterification of iso-Octanol with Acetic Acid using Acid Ionic Liquid as Catalyst

Du Huan, Song Lelian, Tan Zhongqin and Xiaoxiang Han*

Department of Applied Chemistry, College of Food Science & Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, P.R. China

*Corresponding author: Tel: +86 571 88071024 7581; E-mail: hxx74@126.com; han-xx74@163.com


Response surface methodology was successfully applied to optimize esterification of iso-octanol with acetic acid. The effects of various reaction conditions, including reaction time, substrate molar ratio, the amount of catalyst and the amount of water carrying agent were investigated. A Box-Behnken Design was employed to search for the optimal yield of iso-octyl acetate. The analysis confirmed that the reaction time and the amount of water carrying agent were the significant factors affecting the yield of iso-octyl acetate. The coefficient of determination of the model was 0.8922. Under the optimized conditions, the yield of iso-octyl acetate reached 95.35 %, in close agreement with values predicted by the mathematical model. The ionic liquids could be reused five times without noticeable drop in activity.


Ionic liquid, Response surface methodology, Isooctyl acetate, Esterification.

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