Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Pengying Li1, Ketki Sahore2, Jianjun Liu1,* and Rajesh K. Singh2,*

1Forestry College, Northwest A and F University, Yangling 712100, P.R. China

2Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy (Under Local Govt. Dept. Punjab) Nangal, Distt. Rupnagar-140126, Punjab, India

*Corresponding authors: E-mail:;


A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, 1H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.


1,4-Dihydropyridine, 2-Aminobenzophenone, Pharmacophore, Antimicrobial activity.

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