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Synthesis and Antimicrobial Evaluation of 2-Aminobenzophenone Linked 1,4-Dihydropyridine Derivatives

Pengying Li1, Ketki Sahore2, Jianjun Liu1,* and Rajesh K. Singh2,*

1Forestry College, Northwest A and F University, Yangling 712100, P.R. China

2Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy (Under Local Govt. Dept. Punjab) Nangal, Distt. Rupnagar-140126, Punjab, India

*Corresponding authors: E-mail: jianjun2013Liu@126.com; rksingh244@gmail.com
Abstract

A series of novel aminobenzophenone linked 1,4-dihydropyridines (1,4-DHPs) hybrids were synthesized by incorporating aminobenzophenone moiety on 1,4-dihydropyridines scaffold (5a-f) and characterized by IR, 1H NMR and CHN elemental analysis. The synthesized compounds were tested for their in vitro antibacterial activity against the Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Among all the synthesized compounds, compounds 5b, 5c and 5e have shown the maximum activity in their group whereas compounds 5a, 5d, 5f have shown the minimum activity.
Keywords

1,4-Dihydropyridine, 2-Aminobenzophenone, Pharmacophore, Antimicrobial activity.
Reference (24)

1.      R.R. Poondra, R.V. Nallamelli, C.L.T. Meda, B.N.V. Srinivas, A. Grover, J. Muttabathula, S.R. Voleti, B. Sridhar, M. Pal and K.V.L. Parsa, Bioorg. Med. Chem. Lett., 23, 1104 (2013); doi:10.1016/j.bmcl.2012.11.121.

 

2.      R. Boer and V. Gekeler, Drugs Future, 20, 499 (1995). 

 

3.      V.M. Briukhanov, Exp. Clin. Pharmacol., 57, 47 (1994).

 

4.      S. Gullapalli and P. Ramarao, Neuropharmacology, 42, 467 (2002); doi:10.1016/S0028-3908(01)00200-3.

 

5.      S. Bahekar and D. Shinde, Acta Pharm., 52, 281 (2002).

 

6.      R. León, C. Ríos, J. Marco-Contelles, O. Huertas, X. Barril, F. Javier Luque, M.G. López, A.G. García and M. Villarroya, Bioorg. Med. Chem., 16, 7759 (2008); doi:10.1016/j.bmc.2008.07.005.

 

7.      J. Marco-Contelles, R. León, C.de los Ríos, A. Samadi, M. Bartolini, V. Andrisano, O. Huertas, X. Barril, F.J. Luque, M.I. Rodríguez-Franco, B. López, M.G. López, A.G. García, M. do Carmo Carreiras and M. Villarroya, J. Med. Chem., 52, 2724 (2009); doi:10.1021/jm801292b.

 

8.      S.Ulloora, R.Shabaraya, R.Ranganathan and A.V.Adhikari, Eur. J. Med. Chem., 70, 341 (2013); doi:10.1016/j.ejmech.2013.10.010.

 

9.      G.A. Wachter, M.C. Davis, A.R. Martin and S.G. Franzblau, J. Med. Chem., 41, 2436 (1998); doi:10.1021/jm9708745.

 

10.  V.L.R. Sana, V.R. Katla, S. Chennamsetty, A. Shaik and N.R. Chamarthi, Der Pharm. Sinica, 4, 10 (2013).

 

11.  A.M. Vijesh, A.M. Isloor, S.K. Peethambar, K.N. Shivananda, T. Arulmoli and N.A. Isloor, Eur. J. Med. Chem., 46, 5591 (2011); doi:10.1016/j.ejmech.2011.09.026.

 

12.  Y.L.N. Murthy, A. Rajack, M.T. Ramji, J. Jesonbabu, C. Praveen and K.A. Lakshmi, Bioorg. Med. Chem. Lett., 22, 6016 (2012); doi:10.1016/j.bmcl.2012.05.003.

 

13.  V. Niraimathi, A.J. Suresh, S. Latha and S.C. Bala, Int. J. Pharm. Pharm. Sci., 4, 212 (2012).

 

14.  D.A. Walsh, Synthesis, 677 (1980); doi:10.1055/s-1980-29169.

 

15.  E.R. Ottosen, M.D. Sørensen, F. Björkling, T. Skak-Nielsen, M.S. Fjording, H. Aaes and L. Binderup, J. Med. Chem., 46, 5651 (2003); doi:10.1021/jm030851s.

 

16.  S. Cortez-Maya, E. Cortes, S. Hernández-Ortega, T. Ramirez Apan and M. Martínez-García, Synth. Commun., 42, 46 (2012); doi:10.1080/00397911.2010.521435.

 

17.  J.P. Liou, C.W. Chang, J.S. Song, Y.N. Yang, C.F. Yeh, H.Y. Tseng, Y.K. Lo, Y.L. Chang, C.M. Chang and H.P. Hsieh, J. Med. Chem., 45, 2556 (2002); doi:10.1021/jm010365+.

 

18.  P. Cheng,  Q. Zhang,  Y-B. Ma,  Z-Y. Jiang,  X. M. Zhang, F.X. Zhang and J.J.  Chen, Bioorg. Med. Chem. Lett., 18, 3787 (2008).

 

19.  R.K. Singh, S. Devi and D.N. Prasad, Arab. J. Chem., doi:10.1016/j.arabjc.2011.11.013.

 

20.  L. Sun, J. Wu, M. Luo, X. Wang, M. Pan, Z. Gou and D. Sun, Molecules, 16, 9739 (2011); doi:10.3390/molecules16119739.

 

21.  A. Sakunpak and P. Panichayupakaranant, Food Chem., 130, 826 (2012); doi:10.1016/j.foodchem.2011.07.088.

 

22.  P. Kaur, H. Sharma, R. Rana, D.N. Prasad and R.K. Singh, Asian J. Chem., 24, 5649 (2012).

 

23.  P. Kaur and R.K. Singh, Chem. Sci. Trans, 2(S1), S295 (2013); doi:10.7598/cst2013.443.

 

24.  Indian Pharmacopoeia, Government of India, Ministry of Health and Welfare, Published by Controller of publication, New Delhi, II, A105 (1996).

 
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