Innovation of Natural Product as Suppository Base

D. Ramya Devi*, K. Malarvizhi, M. Abinaya and B.N. Vedha Hari

Department of Pharmaceutical Technology, School of Chemical and Biotechnology, SASTRA University, Thanjavur-613 401, India

*Corresponding author: Fax: +91 4362 264120; Tel: +91 4362 264101/108 Extn: 116; E-mail: ramya@scbt.sastra.edu

Abstract

The ideal properties of ghee paved the way for the development of natural product suppository using ghee as a suppository base. It has ability to decrease the low density lipoproteins cholesterol level in plasma, the capability of smoothening the skin and its lipophilic character facilitates better absorption. Suppositories administered via vaginal or rectal route melts at the body temperature for the targeted delivery. Sulphanilamide, an antimicrobial drug is used as the model drug. The objective of the present work is to study the role of ghee as a base in addition with bees wax at varying composition like 1:1, 2:1 and 1:2. The prepared suppositories are evaluated for their physical parameters. The influence of polymer like hydroxy propyl methyl cellulose (5, 10 and 15 %) on drug release is also studied. The results proved that increase in ghee ratio enhances the drug release whereas increased ratio of bees wax showed a decline in release.

Keywords

Sulphanilamide, Bees wax, Cow ghee, Hydroxy propyl methyl cellulose.

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