| 2-Arylbenzofurans from the Leaves of Oriental Tobacco and Their Cytotoxicity |
Zhihua Liu1,2, Jingmei Hang2, Wei Zhao2, Yuanxing Duan2, Yaming Wan1,* and Mingming Miao2,* |
1Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650224, P.R. China
2Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
*Corresponding author: E-mail: ygy1110@163.com; mmmiao@cyats.com |
| Abstract
Four types of 2-arylbenzofurans (1-4), including a new compound, tobarylbenzofuran A (1), were isolated from the leaves of oriental tobacco (a variety of Nicotiana tabacum L). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The two compounds were tested for their cytotoxicity against five human tumors (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. The results showed that compound 1 showed notable inhibitory effect against SHSY5Y and MCF7 cell lines, with IC50 values of 3.5 and 1.8 μM, respectively. |
| Keywords
2-Arylbenzofuran, Oriental tobacco, Cytotoxicity, Nicotiana tabacum L. |
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