Green Synthesis of b-(3,4-Dihydroxyphenyl)lactic Acid

Qun-Zheng Zhang1,2, Yi Wang1, Ye-Fei Nan1, Xun-Yu Xiong1, Qing Pan3 and Xun-Li Zhang1,2,*

1College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China

2Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, UK

3Department of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, P.R. China

*Corresponding author: Tel/Fax: +86 29 8838 2693; E-mail:


A new method has been developed for the synthesis of b-(3,4-dihydroxyphenyl)lactic acid, an active ingredient for the treatment of myocardial ischemia. Pd/C catalysts were used in the key reduction reaction to replace the traditionally used toxic Zn/Hg catalysts. A significantly high product yield of 99.7 % was obtained under the optimal reaction conditions, through the use of orthogonal experimental design, when reaction temperature, catalyst (5 % Pd/C) amount and pressure were 60 ºC, 20 wt % and 1.0 MPa, respectively.



-(3,4-Dihydroxyphenyl)lactic acid, Pd/C catalyst, Reduction, Hydrogenation, Orthogonal experimental design, Green synthesis.

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