Effect of Solvents on Selective Molecularly Imprinted Solid-Phase Extraction of Enrofloxacin from Fish Samples

Yun-Kai Lv*, Li-Min Wang, Mi-Ge Zhao, Jing-Qi Zhang and Han-Wen Sun

College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, P.R. China

*Corresponding author: Fax: +86 312 5079628; Tel: +86 312 5079359; E-mail: lvyunkai@hbu.edu.com


A sample preparation method of solid-phase extraction using a molecularly imprinted polymer as selective adsorbent for the enrofloxacin has been developed. The conditioning, loading, washing and eluting solvents were investigated and evaluated by the recovery and retention of enrofloxacin to obtain the optimum conditions of the molecularly imprinted solid-phase extraction (MISPE). Under the optimal solid phase extraction condition, three fluoroquinolones residues in fish were separated and detected by an off-line MIP-SPE-HPLC with better clean-up and enrichment.


Solvents, Molecularly imprinted polymers, Enrofloxacin.

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  • Asian J. Chem. /
  •  2012 /
  •  24(9) /
  •  pp 3909-3912