Comparative Study of Various Green Chemistry Approaches for the Efficient Synthesis of 1,4-Dihydropyridines

Prabhjot Kaur, Heena Sharma, Rekha Rana, D.N. Prasad and Rajesh K. Singh*

Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal, Distt-Rupnagar, 140126, Punjab, India

*Corresponding author: E-mail:


Hantzsch 1,4-dihydropyridine and its derivatives are an important class of bioactive molecules in the pharmaceutical field. The work on this project was started with the objective of synthesizing known 1,4-dihydropyridine by various green chemistry methods like microwave, solvent-free, ultrasonication and compared the results with conventional technique using different aldehydes and 1,3-dicarbonyl compounds as substituents. The twelve known 1,4-dihydropyridines were synthesized and characterized by their TLC, FT-IR and 1H NMR, elemental studies. When all the data cross-examined, it was concluded that microwave, ultrasonic and solvent-free methods were efficient and less time consuming with high yield. At the same time conventional method was time consuming but scalable when compared with other methods.


Green chemistry, 1,4-Dihydropyridine, Conventional, Microwave, Ultrasonic, Solvent-free.

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  • Asian J. Chem. /
  •  2012 /
  •  24(12) /
  •  pp 5649-5651