A Simple, Efficient and Eco-Friendly Synthesis of 2,3-Dihydro-1H-1,5-benzodiazepines Mediated by Tannic Acid under Solvent-Free Condition

Akshdeep Sandhar and Rajesh K. Singh*

Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal-140 126, India

*Corresponding author: E-mail: rksingh244@gmail.com


A rapid and efficient environment friendly multicomponent one-pot synthesis of 2,3-dihydro-1H-1,5-benzodiazepines catalyzed by tannic acid has been described under solvent free condition. Simple and effective method, use of non-hazardous and cheap catalyst, much faster reaction time (50-60 min) and good to excellent yields are the important features of this method.


One-pot synthesis, 1,5-Benzodiazepines, Tannic acid.

   View Article PDF File Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
  • Asian J. Chem. /
  •  2012 /
  •  24(12) /
  •  pp 5643-5645