Synthesis and Biological Activities of New Series of Imidazolidin-2,4-dione Derivatives

A. Jamal Abdul Nasser*, A. Idhayadhulla, R. Surendra Kumar and J. Selvin†

Department of Chemistry, Jamal Mohamed College, Tiruchirappalli-620 020, India E-mail:

†Department of Microbiology, Bharathidasan University. Tiruchirappalli-620 024, India.


3-{[2-Furylmethylene]amino}imidazolidine-2,4-dione (2) was synthesized by compound 1, ethylchloroacetate and fused sodium acetate involved in cyclization method. A series of imidazolidin-2,4-dione derivatives (3a-3f) were synthesized by composition of compound 2 with 4-substituted benzaldehyde and hydrazine hydrate from Mannich base method. The chemical structures of the compounds were conformed by IR, 1H NMR and elemental analysis. The synthesized compounds have been tested in vitro for their antimicrobial action against various strains of bacterial and fungi organisms.


Imidazolidin-2,4-dione, Mannich base, Antimicrobial activity.

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  • Asian J. Chem. /
  •  2010 /
  •  22(8) /
  •  pp 5853-5858