Synthesis of Schiff Base Derived from p-Aminobenzoic Acid by Solvent-Free Reaction Using Jet Milling

Yan-Hua Cai*†, Ru-Fang Peng†, Shi-Jin Chu† and Jing-Bo Yin

School of Materials Science and Engineering, Shanghai University, Jiading, Shanghai-201800, P.R. China E-mail:

†School of Material Science and Engineering, Southwest University of Science and Technology, Mianyan, Sichuan-621010, P.R. China.


A novel synthesis method on solvent-free reaction using jet milling was described. Synthesis of three Schiff bases derived from p-aminobenzoic acid had been achieved by this solvent-free reaction using jet milling and the structures of these compounds had been characterized by Fourier transform infrared spectroscopy, 1H NMR techniques and mass spectrometry. This solvent-free reaction using jet milling not only involved mild conditions, a simple operation and short reaction time, but also gave high yield without waste producing work-up procedures. Simultaneously, the investigation also showed this reaction method was feasible and of benefit to environm


Solvent-free reaction, Jet milling, Schiff base, p-Amino-benzoic acid.

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  • Asian J. Chem. /
  •  2010 /
  •  22(8) /
  •  pp 5835-5840