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A New Lignan from the Fruit of Schisandra propinqua var. propinqua and its Anti-HIV Activity
PENG FAN 1,2, XIN ZHANG 1,2, TAO LI 1,2, YUN DAI 1, GAN-PENG LI 1* and QIU-FEN HU 2*

1Department of Chemistry, Yunnan Nationalities University, Kunming-650031, P.R. China

2Department of Chemistry, Yuxi Teacher's College, Yuxi-653100, P.R. China

E-mail: huqiufena@yahoo.com.cn; ganpeng_li@sina.com
Abstract

Phytochemical investigation of the fruit of Schisandra propinqua var. propinqua led to the isolation and identification of a new lignan named Schproplignan C. It structure was elucidated by spectroscopic methods including extensive 1 D- and 2 D-NMR techniques and its HIV-1 activity was evaluated. It shows an anti-HIV activity with EC50 (median effect concentration) value of 8.26 mg/mL and a therapeutic index (TI) above 22.8.

Keywords

Schisandra propinqua var. propinqua, Schproplignan C, Anti-HIV-1 activity.
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  • Asian J. Chem. /
  •  2010 /
  •  22(3) /
  •  pp 1705-1708