Spectrophotometric Determination of Moprolol in Pure Form and Pharmaceutical Formulations

Rekha Rajeev* and Rajeev Kumar†

Department of Pharmaceutical Analysis, Srinivas College of Pharmacy, Mangalore-574 143, India Tel:(91)(824)2274722; (91)(948)266008; E-mail: rekhavas@gmail.com †Department of Pharmaceutics, Srinivas College of Pharmacy, Mangalore-574 143, India.

Abstract

A simple specific, precise and accurate spectrophotometric method has been developed for the estimation of moprolol in bulk and tablet dosage form. In the developed method DMF and water was used as the solvent. The absorption maximum of the drug was found to be 273 nm. The method was statistically validated according to international conference on harmonization (ICH) guidelines. Per cent mean recovery was obtained to be 99.1 %, whereas the coefficient of variance was found to be less than 2 %. The drug follows a linear Lambert-Beer law relationship with respect to the drug concentration in the range of 10-70 μg/mL, with linearity coefficient of 0.9999.

Keywords

Spectrophotometry, Moprolol.
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  • Asian J. Chem. /
  •  2010 /
  •  22(3) /
  •  pp 1769-1772