Interaction Studies of Bis-(p-aminobenzoato)diaquanickel(II) and Bis-(p-aminobenzoato) triaquacadmium(II) Complexes with Cat Genomic DNA

ALI ARSLANTAS*, MAHMUT SOZMEN† and HACALI NECEFOGLU

Department of Chemistry, Faculty of Arts and Sciences, Kafkas University, Kars-36300, Turkey Fax: (90)(474)2122706; E-mail: arsoz33@gmail.com

†Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey.

Abstract

Bis-(p-aminobenzoato)diaquanickel(II) [Ni(p-H2N-C6H4COO)2· 2H2O] and bis-(p-aminobenzoato)triaquacadmium(II) [Cd(p-H2NC6H4COO) 2·3H2O] complexes derived from p-aminobenzoate are reported. The genomic DNA interactions of these complexes with cat genomic DNA have been investigated with UV spectroscopy, gel electrophoresis and viscosity measurements. Ni(H2N-C6H4COO)2·2H2O and Cd(H2NC6H4COO) 2·3H2Ocomplexes exhibit interaction activities with DNA. The experimental results indicate that the complexes can bind to DNA via an intercalative mode. The intrinsic binding constants of the complexes with genomic DNA are 5.2 × 105 - 2.49 × 105 M-1, respectively.

Keywords

Nickel (II), Cadmium(II), p-Aminobenzoic acid, DNA Binding, Gel electrophoresis.
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  • Asian J. Chem. /
  •  2010 /
  •  22(3) /
  •  pp 1709-1716